Histamine intolerance means you have high histamine levels in your body. It can happen if your body cannot break down histamine. It can affect multiple systems in your body, but gastrointestinal symptoms are most common.
Histamine intolerance is not a sensitivity to histamine but an indication that you’ve developed too much of it. You can be born with this condition or develop it as a result of your genetics, diet, or medications you take.
Learn more about histamine intolerance and what you can to if you have it.
Histamine intolerance is an indication that you have too much histamine in your body. Histamine is a chemical responsible for a few major functions, including:
- sending messages to your brain
- triggering the release of stomach acid to help digestion
- releasing after injury or allergic reaction as part of your immune response
When there’s too much histamine, your body develops histamine intolerance and cannot break it down properly. It can affect many of your typical bodily functions.
Because you have histamine receptors throughout your body, histamine intolerance can affect several body systems. In a small
Histamine intolerance symptoms are nonspecific. That means they can appear like symptoms of other conditions. This can often make it challenging for doctors to diagnose.
Gastrointestinal (GI) symptoms are the most common and include:
- digestive issues
- abdominal pain
- bloating
- diarrhea
- constipation
- flatulence
- nausea
- vomiting
While they may vary, other common reactions associated with this intolerance include:
- headaches or migraine
- nasal congestion or sinus issues
- fatigue
- itchy skin
- hives
- irregular menstrual cycle
In more severe cases of histamine intolerance, you may experience:
- abdominal cramping
- tissue swelling
- high blood pressure
- irregular heart rate
- anxiety
- difficulty regulating body temperature
- dizziness
You naturally produce histamine along with the enzyme diamine oxidase (DAO). DAO is responsible for breaking down histamine that you take in from foods.
If you develop a DAO deficiency and cannot break down histamine, you could develop histamine intolerance.
Things that can affect your DAO enzyme or histamine levels
- Genetics: You may have a gene mutation that causes your body to produce either less DAO or dysfunctional DAO.
- Medications: Some medications can temporarily block DAO functions or prevent production, including:
- phlegm reducers, such as acetylcysteine
- antiemetics, such as metoclopramide
- antiarrhythmics, such as propafenone
- blood pressure medications, such as dihyrdalazine
- antidepressants, such as amitriptyline
- Gastrointestinal (GI) disorders: GI disorders like inflammatory bowel disease (IBD) can cause DAO deficiency.
- Diet: Histamine-rich foods can cause DAO enzymes to function improperly. Some foods can block DAO enzymes or trigger histamine release.
- Bacterial overgrowth: When your body is unable to digest food properly, bacteria grow, causing you to produce too much histamine. Typical DAO enzyme levels cannot break down the increased histamine in your body, causing a reaction.
What diseases cause histamine intolerance?
Histamine intolerance usually stems from an
- colon polyps
- malabsorption
- food allergies
- celiac disease
- IBD, such as Crohn’s disease or ulcerative colitis
- irritable bowel syndrome (IBS)
- functional dyspepsia
- small intestinal bacterial overgrowth
Was this helpful?
Foods to consider limiting
A health-promoting diet contains moderate levels of histamine. However, some foods high in histamine can trigger inflammatory reactions and other negative health events.
The benefits of a histamine-limiting diet are still an uncertain field of study. More research is needed. Limiting these foods may help some but not others.
- alcohol and other fermented beverages
- fermented foods and dairy products, such as yogurt and sauerkraut
- dried fruits
- avocados
- eggplant
- spinach
- processed or smoked meats
- preserved fish and shellfish
- aged cheese
Several foods can also trigger histamine release in your body, such as:
- alcohol
- bananas
- tomatoes
- wheat germ
- beans
- papaya
- chocolate
- citrus fruits
- nuts, specifically walnuts, cashews, and peanuts
- food dyes and other additives
- fish
- pork
Drinks that block DAO production include:
- alcohol
- black tea
- mate tea
- energy drinks
In a
For instance, based on this systematic review, citrus fruits and fish were very low in histamine. Research results also showed that various studies focusing on a low-histamine diet really differed in their approach, and the list of foods to avoid or to consume was significantly different.
The best strategy may be to try eliminating foods you suspect that are adversely contributing to your health events to see if doing so helps or changes your symptoms.
Foods to eat
If you have histamine intolerance, incorporating low-histamine foods into your eating pattern can help reduce symptoms. There are several variations of low-histamine eating plans. It’s important that you consult a healthcare professional such as a dietician before you eliminate foods from your eating plan.
Some foods low in histamine include:
- fresh meat and freshly caught fish
- non-citrus fruits
- eggs
- gluten-free grains, such as quinoa and rice
- dairy substitutes, such as coconut milk and almond milk
- fresh vegetables except for tomatoes, avocados, spinach, and eggplant
- cooking oils, such as olive oil
Other than making changes to your eating pattern, there’s not much you can do to fix histamine intolerance.
Antihistamines may help reduce symptoms in the short term.
A
Before reaching a diagnosis, a doctor will eliminate other possible disorders or allergies that cause similar symptoms.
They may also suggest following an elimination diet for 14–30 days. This diet requires you to remove foods high in histamine or histamine triggers before slowly reintroducing them to watch for new reactions.
A doctor might also request a blood sample to analyze whether you have a DAO deficiency.
Another way to diagnose histamine intolerance is through a prick test. A typical prick test checks for allergic reactions within 20 minutes. But a prick test for histamine intolerance will typically require a
How do you fix histamine intolerance?
Making changes to your eating pattern is the main way you may be able to fix histamine intolerance. Taking antihistamines may help reduce short-term symptoms. Some
What triggers histamine intolerance?
Your body produces histamine. It also produces an enzyme, DAO, that breaks down histamine. If your body has a problem producing DAO, you may develop histamine intolerance. There are many things that may affect DAO production, such as eating too many foods that contain histamines or foods that block DAO, having a genetic mutation, taking certain medications (like acetylcysteine, metoclopramide, propafenone, dihyrdalazine, or amitriptyline), or having IBS.
Histamine intolerance can cause uncomfortable symptoms, but a low-histamine eating plan may help ease symptoms.
Diagnosing histamine intolerance can be challenging as symptoms are similar to other allergens, disorders, or infections. During the diagnosis process, a doctor will need to eliminate similar medical conditions.
If you think you might have an intolerance or are experiencing irregular symptoms, talk with a doctor.
